XOMA Initiates Phase 2b Dose-Ranging Clinical Trial of XOMA 052 in Type 2 Diabetes Patients

XOMA Ltd. (Nasdaq:XOMA – News), a leader in the discovery and development of therapeutic antibodies, announced that enrollment is underway in a 325-patient Phase 2b dose-ranging clinical trial of its antibody candidate, XOMA 052, in Type 2 diabetes patients. The randomized, placebo-controlled trial will be conducted at up to 70 U.S. sites, will evaluate multiple dose levels of XOMA 052 over six months and is intended to guide Phase 3 development. XOMA estimates that top-line results from the study will be available in the first quarter of 2011.

Type 2 diabetes patients enrolled in the trial will be on stable metformin therapy and will receive monthly treatment for six months with one of four doses of XOMA 052 or placebo administered by subcutaneous injection. The primary outcome measure is mean change in glycated hemoglobin, HbA1c, from baseline. [Read the full article]

{loadposition in-article} Oil prices rose above $72 a barrel Tuesday as a weakening U.S. dollar offset concerns about the strength of the global economic recovery.

By early afternoon in Europe, benchmark crude for March delivery was up 40 cents at $72.29 a barrel in electronic trading on the New York Mercantile Exchange. The contract gained 70 cents to settle at $71.89 on Monday.

Traders often buy commodities such as oil as a hedge against inflation and a weaker dollar and sell them when the U.S. currency rises. Oil, which is priced in dollars, become less expensive in other currencies when the greenback weakens.

Investors nonetheless remain concerned about swelling debt levels in Europe, high unemployment in the U.S. and fears of Chinese monetary tightening continue to cast doubt over the global economic recovery. [Read the full article]

Japan Airlines (Tokyo:9205.T – News) said it would keep its partnership with American Airlines (NYSE:AMR – News) in the Oneworld alliance, ending an attempt by Delta Air Lines (NYSE:DAL – News) to entice the bankrupt carrier to its rival SkyTeam group.

JAL, Asia’s largest carrier by revenues, said it would file with American Airlines for regulatory approval for closer cooperation on transpacific routes under a recently signed “open skies” treaty between the United States and Japan.

The decision is a blow to Delta which had been courting the Japanese carrier for months with an offer of $1 billion in financial aid, eager to gain access to its vast network in Asia and position itself for an expansion of Tokyo’s Haneda Airport. [Read the full article]

{loadposition in-article-finance}

A simple, low-cost solution that delivers ongoing professional portfolio management to help investors navigate complex market dynamics

E*TRADE FINANCIAL Corp. (NASDAQ: ETFC – News) today announced that E*TRADE Capital Management, LLC, has expanded its high-quality advice offerings with the addition of actively managed portfolios of leading, non-proprietary mutual funds or ETFs, which allocate assets based on the customer investment profile.

Managed Investment Portfolios make one-on-one professional portfolio management accessible to investors with an investment of $25,000 or more” a fraction of what many investment advisers require to access their services. [Read the full article]

You may also like...